Purpose: This study examined the relationship between health information systems (HIS) usage and service delivery efficiency in Zambian healthcare facilities. It aimed to determine how system usage affects patient waiting time, accuracy of patient records, and overall operational performance.

Methodology/Design: A quantitative research design was employed, targeting 480 healthcare workers across selected public healthcare facilities. Data were collected using structured questionnaires and analyzed using Structural Equation Modeling (SEM). Reliability and validity were ensured through Cronbach’s Alpha, Composite Reliability, and Confirmatory Factor Analysis.

Findings: The results revealed significant positive relationships between HIS usage and all service delivery indicators. Higher system usage was associated with shorter patient waiting times, improved accuracy of patient records, and enhanced overall service delivery efficiency. These findings align with the Technology Acceptance Model and Task–Technology Fit Theory, showing that effective system adoption improves workflow and data management.

Implications: The study highlights the importance of investing in training, system usability, and workflow alignment to maximize the benefits of HIS. Policymakers and healthcare managers can use these insights to improve operational efficiency, reduce delays, and enhance data quality in healthcare facilities.